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Results for "

cancerous inhibitor of protein phosphatase 2A,CIP2A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nuclear Factor of activated T Cells (NFAT) (1) Phosphatase (196) PTEN (4) SHP2 (18) 5-HT Receptor (5) AAK1 (1) ADAMTS (1) Akt (7) Aldose Reductase (1) AMPK (1) Amyloid-β (2) Androgen Receptor (3) Antibiotic (22) Antifolate (1) Apoptosis (41) ATM/ATR (1) Autophagy (9) Bacterial (19) Bcl-2 Family (2) BCRP (1) Beta-secretase (1) Biochemical Assay Reagents (22) Btk (2) c-Met/HGFR (1) Calcineurin (3) CaMK (1) Carbonic Anhydrase (1) Caspase (4) Cathepsin (1) CCR (1) CD73 (1) CDK (3) CGRP Receptor (1) Cholinesterase (ChE) (6) Complement System (2) COX (2) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (2) DNA/RNA Synthesis (3) Dopamine β-hydroxylase (1) Drug Metabolite (5) Drug-Linker Conjugates for ADC (2) EBV (1) EGFR (4) Endogenous Metabolite (29) Epigenetic Reader Domain (1) Epoxide Hydrolase (1) ERK (3) Ferroptosis (1) FKBP (3) Flavivirus (3) FLT3 (1) Fluorescent Dye (19) Fungal (10) G-quadruplex (1) GABA Receptor (1) GCGR (1) Glucosidase (3) GPR55 (1) GSK-3 (1) HBV (1) HDAC (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (5) HIV (6) HIV Protease (1) HSP (5) HSV (1) IAP (2) iGluR (2) IKK (1) Influenza Virus (1) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (17) JNK (1) Kallikrein (1) Keap1-Nrf2 (1) Leukotriene Receptor (1) Liposome (5) LPL Receptor (1) mAChR (1) MAP3K (1) MAPKAPK2 (MK2) (2) MDM-2/p53 (1) MEK (2) Microtubule/Tubulin (2) MMP (2) Molecular Glues (1) Monoamine Oxidase (5) mTOR (2) NAMPT (1) Neurokinin Receptor (3) NF-κB (3) NO Synthase (1) NOD-like Receptor (NLR) (1) Notch (1) P-glycoprotein (1) p38 MAPK (2) Parasite (17) PD-1/PD-L1 (2) PERK (1) PGE synthase (1) Phosphodiesterase (PDE) (1) Phospholipase (2) PI3K (1) PKC (2) Potassium Channel (1) Progesterone Receptor (2) Prostaglandin Receptor (2) PROTACs (6) Protease Activated Receptor (PAR) (1) Pyk2 (1) Raf (2) Ras (2) Reactive Oxygen Species (5) Renin (1) RET (1) Reverse Transcriptase (2) ROCK (1) ROR (2) ROS Kinase (1) SARS-CoV (4) Ser/Thr Protease (6) Serotonin Transporter (1) Sirtuin (2) Sodium Channel (1) STAT (2) STING (5) TGF-β Receptor (2) Thyroid Hormone Receptor (1) Tie (1) TNF Receptor (4) Topoisomerase (3) TRP Channel (1) Tryptophan Hydroxylase (1) VD/VDR (7) Wnt (1)
By Research Areas:	Cancer (205) Cardiovascular Disease (18) Endocrinology (17) Infection (58) Inflammation/Immunology (63) Metabolic Disease (84) Neurological Disease (54)
Click Chemistry:	Alkynes (7)

504

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

242

Recombinant Proteins

Isotope-Labeled Compounds

115

Antibodies

Click Chemistry

Targets Recommended: Phosphatase PTEN SHP2 Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2818

*Alkaline phosphatase, Bovine intestine* 1 Publications Verification Apase	Endogenous Metabolite	Metabolic Disease Cancer
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-N4317

Ethoxysanguinarine 1 Publications Verification	Apoptosis	Cancer
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of *protein phosphatase* 2A** (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth .

HY-139296

*PP2A Cancerous-IN-1*	Akt	Cancer
PP2A Cancerous-IN-1 is a strong and potent *CIP2A* (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities . PP2A Cancerous-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-156970

Phosphatase Binder-1	Others	Cancer
Phosphatase Binder-1 (comppund i-196) provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Phosphatase Binder-1 plays an important role in cancer .

HY-149492

Phosphatase-IN-1	Phosphatase Fungal	Infection
Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a *phosphatidate phosphatase* (Pah)** inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads .

HY-W040256

*Acid phosphatase, wheat* ACP	Endogenous Metabolite	Metabolic Disease
Acid phosphatase, wheat (ACP) is an enzyme that removes phosphate from other molecules during digestion. Acid phosphatase catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid .

HY-D1676

Thymolphthalein monophosphate disodium hydrate	Phosphatase	Others
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum .

HY-78144

4-Methylsalicylic acid	IAP	Inflammation/Immunology
4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor .

HY-145379

Miaosporone A	Parasite Endogenous Metabolite	Infection
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-D1491

Fast Red Violet LB	Fluorescent Dye	Others
Fast Red Violet LB is a dye for staining tartrate resistant acid phosphatase (TRAP). Fast Red Violet LB can be used for alkaline phosphatase (ALP) activity staining .

HY-D1491A

Fast Red Violet LB Zinc chloride	Fluorescent Dye	Others
Fast Red Violet LB Zinc chloride is a stain that stains tartrate-resistant acid phosphatase (TRAP) and Fast Red Violet LB Zinc chloride can be used to stain alkaline phosphatase (ALP) activity .

HY-N10186

Dibefurin

Phosphatase Endogenous Metabolite Others

Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase .

Dibefurin	Phosphatase Endogenous Metabolite	Others
Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase .

HY-120166

DiFMUP 6,8-Difluoro-4-methylumbelliferyl phosphate	Phosphatase	Others
DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader .

HY-N12613

Sydowimide A	Phosphatase	Inflammation/Immunology
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-133511

MLS000544460	Phosphatase	Cancer
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K_d of 2.0 μM and an IC₅₀ of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity .

HY-W013478

PTP inhibitor 1

Phosphatase Cancer

PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect .

PTP inhibitor 1	Phosphatase	Cancer
PTP inhibitor 1 is a *protein tyrosine phosphatase* (PTP)** inhibitor, with anti-angiogenic effect .

HY-155374

PP5-IN-1	Phosphatase Apoptosis	Cancer
PP5-IN-1 (Compound P053) is a competitive inhibitor of *Serine/threonine protein phosphatase-5 (PP5)* that binds to its catalytic domain and causes apoptosis in renal cancer .

HY-D1208

CDP-Star

Biochemical Assay Reagents Phosphatase Others

CDP-Star is a chemiluminescent substrate for alkaline phosphatase. CDP-Star can be used for enzyme-linked immunoassays .

CDP-Star	Biochemical Assay Reagents Phosphatase	Others
CDP-Star is a chemiluminescent substrate for alkaline phosphatase. CDP-Star can be used for enzyme-linked immunoassays .

HY-P5363

PAP 248–286 Prostatic Acid phosphatase(248-286)	HIV	Others
PAP 248–286 is a biological active peptide. (Prostatic Acid Phosphatase (248-286), PAP (248-286) peptide is a semen-derived enhancer of viral infection (SEVI) factor found in semen. This peptide greatly increases HIV infection through enhanced virion attachment to target cells.)

HY-152168

NSC 295642	PERK Phosphatase	Cancer
NSC 295642 is a *phosphatase* inhibitor. NSC 295642 can significantly increase phospho-Erk cytonuclear differences in intact cells. NSC 295642 can be used for the research of cancer .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Phosphatase	Neurological Disease Metabolic Disease
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-13588

Cefsulodin sodium SCE-129 sodium	Bacterial Antibiotic	Infection
Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-128153

Thienopyridone	Phosphatase Apoptosis	Cancer
Thienopyridone is a potent and selective **phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC₅₀s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3*, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis* and has anticancer effects .

HY-18667

LTV-1	Phosphatase	Inflammation/Immunology
LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC₅₀ of 508 nM. LTV-1 has the potential for autoimmunity treatment .

HY-127178

ML120 analog 1

Phosphatase Cancer

ML120 analog 1 (compound 1) is a competitive inhibitor with a K_i of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) .

ML120 analog 1	Phosphatase	Cancer
ML120 analog 1 (compound 1) is a competitive inhibitor with a K_i of 0.69 μM for *Hematopoietic protein tyrosine phosphatase* (HePTP)** .

HY-D0994

4-Methylumbelliferyl phosphate 4-MUP; MUP	Phosphatase	Others
4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline *phosphatase* fluorogenic substrate. 4-Methylumbelliferyl phosphate is also a nerve agent simulant .

HY-B2203

Calcium glycerophosphate	Phosphatase	Metabolic Disease
Calcium glycerophosphate is an inhibitor of *intestinal alkaline phosphatase* F3**. Calcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions .

HY-121087

BCI-215 2 Publications Verification	Phosphatase	Cancer
BCI-215 is a potent and tumor cell-selective *dual specificity MAPK phosphatase* (DUSP-MKP)** inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells .

HY-111489

LMPTP inhibitor 1	Phosphatase	Metabolic Disease
LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC₅₀ of 0.8 μM LMPTP-A.

HY-116022A

4-Nitrophenyl phosphate disodium hexahydrate 2 Publications Verification p-Nitrophenyl phosphate disodium hexahydrate	Biochemical Assay Reagents	Others
4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .

HY-P0320A

EGF Receptor Substrate 2 (Phospho-Tyr5) (TFA)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-P0320B

EGF Receptor Substrate 2 (Phospho-Tyr5) (acetate)	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-123856

MY10	Phosphatase	Neurological Disease
MY10 is a potent and orally active *receptor protein tyrosine phosphatase* (RPTPβ/ζ)** inhibitor. MY10 attenuates binge-like ethanol consumption and ethanol reward .

HY-149942

PAP-IN-1	Others	Others
PAP-IN-1 (compound 28) is an inhibitor of purple acid phosphatases (PAPs), a ubiquitous binuclear metallohydrolase. PAP-IN-1 inhibits mammalian PAP with K_i value of 168 nM. PAP-IN-1 targets to pig PAP with K_ic value of 0.17 μM. PAP inhibitors can be used for research of anti-osteoporotic drugs .

HY-19820A

NSC45586 sodium	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 sodium is an inhibitor of *pleckstrin homology domain and leucine-rich repeat protein phosphatase* (PHLPP)*. NSC45586 sodium targets the PP2C phosphatase* domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons .

HY-19820

NSC45586	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 is an inhibitor of *pleckstrin homology domain and leucine-rich repeat protein phosphatase* (PHLPP)*. NSC45586 targets the PP2C phosphatase* domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons .

HY-15756

PTP1B-IN-4	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC₅₀ of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .

HY-P1247

Calcineurin autoinhibitory peptide	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide is a selective inhibitor of *Ca ²⁺/calmodulin-dependent protein phosphatase* (calcineurin), with an IC₅₀** of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death .

HY-N4143

Cyanidin 3-arabinoside	Phosphatase	Metabolic Disease
Cyanidin 3-arabinoside is a selective and reversible *protein tyrosine phosphatase* 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-120272

SMAP-2

DT-1154
Phosphatase Cancer

SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity .

SMAP-2 DT-1154	Phosphatase	Cancer
SMAP-2 (DT-1154) is an orally active *protein phosphatase* 2A (PP2A)** activator, with anti-cancer activity .

HY-P1247A

Calcineurin autoinhibitory peptide TFA	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of *Ca ²⁺/calmodulin-dependent protein phosphatase* (calcineurin), with an IC₅₀** of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death .

HY-126326

SWE101	Epoxide Hydrolase	Metabolic Disease
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC₅₀s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH .

HY-108547

Alexidine dihydrochloride	Fungal Apoptosis	Infection
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .

HY-N7599

Chrysophanol triglucoside	Phosphatase Glucosidase	Metabolic Disease
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits *protein tyrosine phosphatases* 1B (PTP1B) and α-glucosidase with IC₅₀**s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

HY-N12177

Cryptosporioptide A	Phosphatase	Metabolic Disease
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-N10223

Phostriecin	Antibiotic Phosphatase	Infection Inflammation/Immunology Cancer
Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC₅₀s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer .

HY-N2511

Trimyristin	Cholinesterase (ChE) Phosphatase Endogenous Metabolite	Metabolic Disease
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-P5984A

Thioether-cyclized helix B peptide, CHBP TFA	mTOR	Others
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-111022

Icerguastat Sephin1; IFB-088	Phosphatase	Infection Inflammation/Immunology
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2818

*Alkaline phosphatase, Bovine intestine* 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-N4317

Ethoxysanguinarine 1 Publications Verification	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Cancer	Apoptosis
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of *protein phosphatase* 2A** (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth .

HY-W040256

*Acid phosphatase, wheat* ACP	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Acid phosphatase, wheat (ACP) is an enzyme that removes phosphate from other molecules during digestion. Acid phosphatase catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-P2040

Nodularin	Structural Classification other families Cyclopeptides Ketones, Aldehydes, Acids Source classification Marine natural products Plants	Others
Nodularin is a potent hepatotoxin, tumor promoter, and protein phosphatase inhibitor .

HY-N10186

Dibefurin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Phosphatase Endogenous Metabolite
Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase .

HY-N12613

Sydowimide A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Phosphatase
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Cassia obtusifolia L. Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N4143

Cyanidin 3-arabinoside	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Phosphatase
Cyanidin 3-arabinoside is a selective and reversible *protein tyrosine phosphatase* 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-N7599

Chrysophanol triglucoside	Quinones Monophenols Classification of Application Fields Cassia obtusifolia L. Anthraquinones Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase Glucosidase
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits *protein tyrosine phosphatases* 1B (PTP1B) and α-glucosidase with IC₅₀**s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

HY-N12177

Cryptosporioptide A	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Phosphatase
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-N10223

Phostriecin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Antibiotic Phosphatase
Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC₅₀s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer .

HY-N2511

Trimyristin	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N6785

Okadaic acid 5+ Cited Publications	Structural Classification Animals Ketones, Aldehydes, Acids Marine natural products Source classification Other marine organisms	Phosphatase Apoptosis
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation .

HY-N6258

Kahweol	other families Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Diterpenoids Plants Disease Research Fields Coffea arabica L.	AMPK Apoptosis
Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

HY-N3267

Methyl pseudolarate B	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Pseudolarix amabilis (J. Nelson) Rehder Plants	Phosphatase
Methyl pseudolarate B, a natural diterpenoid, is a *protein tyrosine phosphatase* 1B (PTP1B)** (Phosphatase) inhibitor with an IC₅₀ value of 10.9 μM .

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Source classification Phenols Polyphenols Agavaceae Plants	Phosphatase
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of *alkaline phosphatase* (ALP)** activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent *protein tyrosine phosphatase* 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy** through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-N4185

Licoflavone A 1 Publications Verification	Flavonoids Neurological Disease Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Phosphatase
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-B0579

Cyclosporin A Maximum Cited Publications 99 Publications Verification Cyclosporine A; Ciclosporin A; CsA	Structural Classification Natural Products Microorganisms Classification of Application Fields Anti-aging Source classification Inflammation/Immunology Disease Research Fields Cancer	Molecular Glues Phosphatase Complement System Antibiotic
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of *protein phosphatase* 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18** adhesion .

HY-W008385

H-HoArg-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-W018772

D-Ribose(mixture of isomers) 3 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Cancer	Endogenous Metabolite
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-N6013

Aloin(mixture of A&B)	Infection Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	MMP Bacterial Fungal
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs) .

HY-131152

Leucinostatin (mixture of A&B)	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Antibiotic
Leucinostatin (mixture of A&B), the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus, are antibiotics .

HY-N10649

PTP1B-IN-21	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-21 is a selective inhibitor of *protein tyrosine phosphatase* 1B (PTP1B; IC₅₀*=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase* (TCPTP; IC₅₀>100 μM), which is a key target for type 2 diabetes inhibition .

HY-N10648

PTP1B-IN-20	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-20 is a selective inhibitor of *protein tyrosine phosphatase* 1B (PTP1B; IC₅₀*=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase* (TCPTP; IC₅₀=78.0 μM), which is a key target for type 2 diabetes inhibition .

HY-N8789

2-Hydroxymethyl-3-hydroxyanthraquinone	Quinones Anthraquinones Rubiaceae Plants Morinda officinalis How	Phosphatase
2-Hydroxymethyl-3-hydroxyanthraquinone is an antiosteoporotic compound that inhibits osteoclastic *tartrate-resistant acid phosphatase* (TRAP)** activity .

HY-114336

Enocyanin 1 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology	Phosphatase
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-N12736

Dehydrodanshenol A	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	Phosphatase
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .

HY-N6650

Isotanshinone IIA	Quinones Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Metabolic Disease Plants Naphthalene Quinones Disease Research Fields	Phosphatase
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-W355141

Isopulegol	Structural Classification Natural Products Classification of Application Fields Source classification Essence, Fragrance Myrtaceae Cosmetic Research Plants Disease Research Fields Cancer Eucalyptus citriodora Hook. f.	Others
Isopulegol is one of the main components of ECO (Eucalyptus citriodora oil). ECO has antibacterial activity .

HY-116757

(±)-α-CMBHC	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(±)-α-CMBHC is a metabolite of α-Tocopherol .

HY-N0374

Licochalcone C 2 Publications Verification	Flavonoids Chalcones Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Glucosidase
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

HY-P0219

Microcystin-LA	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Phosphatase
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC₅₀s of 0.3 and 0.3 nM, respectively .

HY-139637

(±)-Silybin Silibinin (mixture of Silybin A and Silybin B)	Structural Classification Flavanonols Flavonoids Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Others
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity .

HY-106702

Fostriecin sodium CI-920	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Phosphatase
Fostriecin (sodium) (compound 1, CI-920) is an antibiotic with a cytotoxic activity. Fostriecin (sodium) is also an inhibitor of protein phosphatase including PP4 (IC₅₀= 3 nM)and PP2 (IC₅₀=1.5 nM) .

HY-13756A

Tacrolimus monohydrate 65+ Cited Publications FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Autophagy Bacterial Antibiotic
Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-N10064

Ficusonolide	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Others
Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

HY-119539

Limocitrin	Structural Classification Flavonols Flavonoids Source classification Plants Platanaceae Platanus orientalis L.	Phosphatase
Limocitrin is a natural product that can be isolated from the buds of P. acerifolia and P. orientalis. Limocitrin suppresses estradiol-dependent proliferation of MCF7 cells weakly but estradiol-induced AlkP (alkaline phosphatase) expression only marginally .

HY-13756

Tacrolimus 65+ Cited Publications FK506; Fujimycin; FR900506	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Animals Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	Phosphatase FKBP Bacterial Autophagy Antibiotic
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-N2451

Aloe-emodin-8-O-β-D-glucopyranoside 1 Publications Verification	Quinones Structural Classification Monophenols Liliaceae Classification of Application Fields Anthraquinones Source classification Phenols Aloe vera (L.) Burm. f. Metabolic Disease Plants Disease Research Fields	Phosphatase
Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of *human protein tyrosine phosphatase* 1B (hPTP1B) with an IC₅₀** of 26.6 μM .

HY-W661499

Orellanine	Structural Classification Natural Products Microorganisms Source classification	Phosphatase
Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC) .

HY-N8366

Alloisoimperatorin	Structural Classification Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt.	Phosphatase
Alloisoimperatorin (Compound 5) is a phytoestrogen that can be isolated from Angelica dahurica. Alloisoimperatorin can induce alkaline phosphatase (AP) activity with an EC₅₀ of 0.8 μg/mL. Alloisoimperatorin can be used in the study of hormone-dependent cancers and the alleviation of menopausal symptoms .

HY-B1341

Norethynodrel Enidrel; SC 4642; NSC 15432	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
Norethynodrel (Enidre) is a 19-nortestosterone derivative to be used as a progestagen. Norethynodrel can be used for researching inhibition of ovulation . Norethynodrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1651

2,3',4,6-Tetrahydroxybenzophenone	Structural Classification Gentiana lutea L. Source classification Gentianaceae Phenols Polyphenols Plants	Others
2,3',4,6-Tetrahydroxybenzophenone, a kind of benzophenone, is the immediate precursor of xanthones in higher plants .

HY-N8549A

5-Dihydrocortisone	Structural Classification Classification of Application Fields Cardiacglycosides Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver

HY-N2116

Ginkgolic acid C17:1	Monophenols Classification of Application Fields Ginkgoaceae Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields Ginkgo biloba Cancer	PTEN Phosphatase
Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects .

HY-N8200

Cassiaside B2	Monophenols Classification of Application Fields Cassia obtusifolia L. Source classification Phenols Caesalpiniaceae Plants Disease Research Fields Inflammation/Immunology	Phosphatase Monoamine Oxidase 5-HT Receptor
Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..

HY-N11441

cis-Ferulic acid 4-O-β-D-glucopyranoside	Structural Classification Ketones, Aldehydes, Acids Zygophyllaceae Source classification Plants Nitraria sibirica Pall	Phosphatase
cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7) is a phenolic glycosid, which can be isolated from Nitraria sibirica.. cis-Ferulic acid 4-O-β-D-glucopyranoside exhibits antioxidant activity and potent inhibitory effect on Phosphatase PTP1B .

HY-N0646

Silydianin 1 Publications Verification	Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Phosphatase Endogenous Metabolite
Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural *protein tyrosine phosphatase* 1B (PTP1B) with an IC₅₀** of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products .

Cat. No.	Product Name	Chemical Structure

HY-B0537AS

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

HY-132485S

N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers)

N-Methyl Pantoprazole-d3 (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers) .
HY-132676S

Ramiprilat-d5 (Mixture of Diastereomers)

Ramiprilat-d₅ (Mixture of Diastereomers) is the deuterium labeled Ramiprilat (Mixture of Diastereomers)[1].

HY-B0579S2

Cyclosporin A acetate-d4
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of *protein phosphatase* 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18** adhesion .

HY-151002S

M8 metabolite of Carvedilol-d5

M8 metabolite of Carvedilol-d₅ is the deuterium labeled M8 metabolite of Carvedilol[1].
HY-132382S

β-Sitosterol-d7 (mixture of diasteromers)

β-Sitosterol-d₇ (Mixture of Diastereomers) is the deuterium labeled β-Sitosterol (mixture of diasteromers)[1].

HY-132706S

N-Deformyl Formoterol-d6 Fumarate (Mixture of Diastereomers)
N-Deformyl Formoterol-d₆ Fumarate (Mixture of Diastereomers) is the deuterium labeled N-Deformyl Formoterol Fumarate (Mixture of Diastereomers)[1].

HY-132637S

Chlorfenvinphos-d10(Mixture of cis-trans isomers)

Chlorfenvinphos-d₁₀(Mixture of cis-trans isomers) is the deuterium labeled Chlorfenvinphos (Mixture of cis-trans isomers)[1].

HY-W018772S15

D-Ribose(mixture of isomers)-13C5

D-Ribose(mixture of isomers)- ¹³C₅ isomers)- ¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].

HY-W008385S

H-HoArg-OH-d4

H-HoArg-OH-d₄ is a deuterium labeled H-HoArg-OH (HY-W008385). H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-132379S

Hydroxy Pioglitazone-d5 (M-IV) (Mixture of-diastereomers)
Hydroxy Pioglitazone-d₅ (M-IV) (Mixture of-diastereomers) is the deuterium labeled Hydroxy Pioglitazone (M-IV) (Mixture of-diastereomers)[1].

HY-134670S

α-Hydroxy Metoprolol-d5 (Mixture of Diastereomers)

α-Hydroxy Metoprolol-d₅ (Mixture of Diastereomers) is the deuterium labeled α-Hydroxy Metoprolol Mixture of Diastereomers[1].

HY-B0579S3

Cyclosporin A-13C2,d4
Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of *protein phosphatase* 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18** adhesion .

HY-B2006S

Fenvalerate-d5
Fenvalerate-d₅ is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

HY-B0579S

Cyclosporin A-d4
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers)
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .

HY-13632S5

Exemestane-13C,d2
Exemestane- ¹³C,d₂ is ¹³C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC₅₀s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research .

HY-113026S

(2RS,4R,8R)-δ-Tocopherol-d4 (Mixture of Diastereomers)
(2RS,4R,8R)-δ-Tocopherol-d₄ (Mixture of Diastereomers) is the deuterium labeled (2RS,4R,8R)-δ-Tocopherol (Mixture of Diastereomers)[1].

HY-150857S

Thymine-α,α,α,6-d4 Glycol (mixture of diastereomers)-d4
Thymine-α,α,α,6-d₄ Glycol (mixture of diastereomers)-d₄ is the deuterium labeled Thymine-α,α,α,6-d4 Glycol (mixture of diastereomers)[1].

HY-13756S

Tacrolimus-13C,d2
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

HY-106827S1

Trimegestone-13C,d3

Trimegestone- ¹³C,d₃ is ¹³C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC₅₀ value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC₅₀=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes .

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